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KMID : 0370019910050000047
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Chung-Ang Journal of Pharmacal Sciences
1991 Volume.5 No. 0 p.47 ~ p.53
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Effect of Antacids on the Pharmacokinetics of Norfloxacin in Rats
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Abstract
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The effect of antacids on the pharmacokinetic parameters(mean±S.E.) was inverstigated in rats. The pharmacokinetic data were evaluated by the residual method assuming one compartment open model. K_ei, t_1/2β, K_a, t_1/2α and Cp^max in the oral administration of norfloxacin were 0.138hr^-1, 5.05hr, 1.356hr^-1, 0.61hr, 10.074㎍/㎖, respectively and these parameter values were significantly increased or decreased according to the type of antacids, when norfloxacin and antacids were concurrently administered. AUC in case of the administration of norfloxacin alone was 62.49㎍ · hr · ㎖^-1, and AUC was significantly decreased in case of the concurrent administration of norfloxacin and antacids(except magnesium oxide 1×0.5g/kg and aluminum hydroxide gel 2×0.3g/kg). The bioavailability of norfloxacin was generally decreased by the coadministration of antacids on the basis of Cp^max, T_max and AUC data.
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KEYWORD
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